EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.114 | expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
2.1.1.114 | expressed in Escherichia coli BL21(DE3) cells | Escherichia coli |
2.1.1.222 | expressed in Escherichia coli BL21(DE3) cells | Escherichia coli |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.1.114 | - |
Escherichia coli |
2.1.1.222 | - |
Escherichia coli |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.222 | H186A | the mutation completely destroys the interaction of the enzyme with liposomes | Escherichia coli |
2.1.1.222 | I177A | the mutation sharply reduces the interaction of the enzyme with liposomes | Escherichia coli |
2.1.1.222 | K183A | the mutation nearly completely destroys the interaction of the enzyme with liposomes | Escherichia coli |
2.1.1.222 | L178A | the mutation nearly completely destroys the interaction of the enzyme with liposomes | Escherichia coli |
2.1.1.222 | L178E | the mutation nearly completely destroys the interaction of the enzyme with liposomes | Escherichia coli |
2.1.1.222 | R179A | the mutation sharply reduces the interaction of the enzyme with liposomes | Escherichia coli |
2.1.1.222 | V181A | the mutation nearly completely destroys the interaction of the enzyme with liposomes | Escherichia coli |
2.1.1.222 | V181A/P182A/K183A/G184A/T185A/H186A | the mutations nearly completely destroy the interaction of the enzyme with liposomes | Escherichia coli |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.1.1.114 | mitochondrial membrane | - |
Homo sapiens | 31966 | - |
2.1.1.114 | plasma membrane | - |
Escherichia coli | 5886 | - |
2.1.1.222 | membrane | - |
Escherichia coli | 16020 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate | Homo sapiens | - |
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate | - |
? | |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate | Escherichia coli | - |
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.114 | Escherichia coli | P17993 | - |
- |
2.1.1.114 | Homo sapiens | - |
- |
- |
2.1.1.222 | Escherichia coli | P17993 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.114 | Ni-NTA column chromatography and Superdex 200 gel filtration | Homo sapiens |
2.1.1.114 | Ni-NTA column chromatography and Superdex 200 gel filtration | Escherichia coli |
2.1.1.222 | Ni-NTA column chromatography, HiTrap column chromatography, and Superdex 200 gel filtration | Escherichia coli |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate | - |
Homo sapiens | S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate | - |
? | |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate | - |
Escherichia coli | S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.1.114 | monomer | x-ray crystallography | Escherichia coli |
2.1.1.222 | monomer | x-ray crystallography | Escherichia coli |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.114 | COQ3 | - |
Homo sapiens |
2.1.1.114 | UbiG | - |
Escherichia coli |
2.1.1.222 | UbiG | - |
Escherichia coli |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.222 | S-adenosyl-L-methionine | dependent on | Escherichia coli |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.114 | physiological function | the primary role of the enzyme is to serve as an electron carrier in the respiratory electron transport chain in the mitochondrial inner membrane | Homo sapiens |
2.1.1.114 | physiological function | the primary role of the enzyme is to serve as an electron carrier in the respiratory electron transport chain in the plasma membrane | Escherichia coli |